NATYR Intensive Serum Detox Antiaging 30 ml should be applied twice daily to the face and neck. As drinking water should be filtered through a charcoal filter. Soak a cotton ball or pad in this serum, after the cotton is already moistened with serum it is applied. Leaves on the face for 5-10 minutes before you rinse it off. For optimal results use this product in conjunction with other products from the NATYR range.